BAMLET administration into the stomach or in the drinking water markedly reduced colon cancer development in susceptible mice. The effect was quantified as a reduction in tumor number and tumor size after 2 weeks. Long-term effects were also found in mice that had been treated for 27 weeks, which survived longer than untreated controls, where the disease developed faster. BAMLET was taken up by tumour tissue and was shown to lower the cellular content of several cancer markers. Strikingly, cancer gene expression was inhibited in the treatment group, suggesting a pronounced effect and a return towards health.

Colon cancer is the third most deadly and fourth most commonly diagnosed cancer in world. The Apc[Min][/+]model mimics human disease, especially familial polyposis where APC mutations increase colon cancer susceptibility. The results suggest that local BAMLET treatment may be effective against colon cancer also in man, with a therapeutic and prophylactic potential. Clinical studies will be required to more precisely define the clinical potential of BAMLET therapy in colon cancer.  

This disclosure contains information that Hamlet is obliged to make public pursuant to the EU Market Abuse Regulation (EU nr 596/2014). The information was submitted for publication, through the agency of the contact person, on 06-10-2020 10:31 CET.